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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
16.36
Human Site:
S24
Identified Species:
25.71
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
S24
A
C
S
Q
P
H
G
S
V
T
Q
S
Q
G
S
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
S24
A
C
S
Q
P
H
G
S
V
T
Q
S
Q
G
S
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
S24
T
C
S
Q
P
H
G
S
V
T
Q
S
Q
G
S
Dog
Lupus familis
XP_543464
544
61233
T24
A
C
S
Q
S
Q
G
T
F
S
Q
S
Q
G
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
G33
G
G
F
S
Q
P
Q
G
T
P
S
Q
L
H
E
Rat
Rattus norvegicus
NP_446129
545
60912
G32
G
G
F
S
Q
S
Q
G
T
P
S
Q
L
H
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
S24
Q
S
Q
N
A
S
S
S
S
S
S
A
T
H
T
Chicken
Gallus gallus
NP_001073576
522
58779
S24
P
S
Q
G
G
T
S
S
S
S
S
A
S
Q
G
Frog
Xenopus laevis
NP_001082016
517
58243
P25
S
S
S
S
S
S
A
P
Q
S
Y
S
Q
S
S
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
Honey Bee
Apis mellifera
XP_624334
480
54300
L10
D
E
Q
I
V
L
T
L
P
P
T
Q
D
A
E
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
S10
E
S
D
M
S
T
A
S
A
G
G
S
A
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
S24
S
F
K
R
Q
Q
R
S
N
K
P
S
S
E
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
93.3
60
N.A.
0
0
N.A.
6.6
6.6
26.6
0
N.A.
0
0
0
20
P-Site Similarity:
100
100
93.3
73.3
N.A.
0
0
N.A.
26.6
20
40
0
N.A.
0
0
0
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
0
0
7
0
14
0
7
0
0
14
7
7
0
% A
% Cys:
0
27
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
7
0
0
0
0
0
0
0
0
0
7
0
7
% D
% Glu:
7
7
0
0
0
0
0
0
0
0
0
0
0
7
14
% E
% Phe:
0
7
14
0
0
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
14
14
0
7
7
0
27
14
0
7
7
0
0
27
7
% G
% His:
0
0
0
0
0
20
0
0
0
0
0
0
0
20
0
% H
% Ile:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
7
% I
% Lys:
0
0
7
0
0
0
0
0
0
7
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
7
0
7
0
0
0
0
14
0
0
% L
% Met:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
0
0
0
0
7
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
20
7
0
7
7
20
7
0
0
0
0
% P
% Gln:
7
0
20
27
20
14
14
0
7
0
27
20
34
7
0
% Q
% Arg:
0
0
0
7
0
0
7
0
0
0
0
0
0
0
0
% R
% Ser:
14
27
34
20
20
20
14
47
14
27
27
47
14
14
34
% S
% Thr:
7
0
0
0
0
14
7
7
14
20
7
0
7
0
7
% T
% Val:
0
0
0
0
7
0
0
0
20
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _